Fig. 3.

FGFR3 mutation mapping and distribution across tumor types. a. A stick plot of FGFR3 showing the locations of mutations in the responders. Red, somatic mutations. Blue, synonymous mutation. b. Structure of the immunoglobulin domain of FGFR3 (PDB code, 1RY7) with mutations identified in the responder cohort. c. The somatic FGFR3 mutation frequency in multiple tumor types from COSMIC. d. Kaplan-Meier curves comparing OS between BC patients expressing high or low levels of FGFR3 using the log-rank test. n, patient number.