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. Author manuscript; available in PMC: 2019 May 21.
Published in final edited form as: Phys Med Biol. 2018 May 21;63(10):105020. doi: 10.1088/1361-6560/aac0bd

Figure 1.

Figure 1

Static Cardiac and Dynamic Arterial (SCDA) MBF Estimation Overview. A dynamic arterial input function is obtained either by direct measurement (the measured AIF method) or prediction via convolution of contrast injection with a timing bolus derived cardiovascular transfer function (the predicted AIF method). This input function is combined with a perfusion model to yield a prediction of the myocardial contrast enhancement over time (myocardial TACs) as a function of MBF. Given the exact timing of the static whole heart myocardial acquisition, an enhancement vs. MBF curve (essentially a lookup table) specific to the patient, injection, and study can be constructed. The measured myocardial enhancement can then be translated to a quantitative MBF estimate using this relationship.