Table 1.
Baseline characteristics in patients with high and low ITGAE+ TIL in FUSCC.
| Variables, N (%) | ITGAE+ TIL |
P value | |
|---|---|---|---|
| Low infiltration (n = 141) | High infiltration (n = 135) | ||
| Gender | |||
| Male | 60(42.6) | 52(38.5) | 0.495 |
| Female | 81(57.4) | 83(61.5) | |
| Age, years | 57.6 ± 11 | 56.7 ± 11 | 0.531 |
| TNM stage | 0.001 | ||
| I | 3(2.1) | 18(13.3) | |
| II | 37(26.2) | 44(32.6) | |
| III | 74(52.5) | 58(43.0) | |
| IV | 27(19.1) | 15(11.1) | |
| N stage | 0.107 | ||
| N0 | 52(36.9) | 68(50.4) | |
| N1 | 45(31.9) | 37(27.4) | |
| N2 | 43(30.5) | 30(22.2) | |
| M stage | 0.063 | ||
| M0 | 114(80.9) | 120(88.9) | |
| M1 | 27(19.1) | 15(11.1) | |
| Grade | 0.805 | ||
| Well/moderate | 113(80.1) | 107(79.3) | |
| poor | 28(19.9) | 28(20.7) | |
| T stage | <0.001 | ||
| T2 | 9(6.4) | 34(25.2) | |
| T3 | 23(16.3) | 31(23.0) | |
| T4 | 109(77.3) | 70(51.9) | |
| Histological type | 0.478 | ||
| Adenocarcinoma | 132(93.6) | 129(95.6) | |
| Mucinous | 9(6.4) | 6(4.4) | |
| Lymph node examined | 0.543 | ||
| Median | 15 ± 5 | 15 ± 6 | |
| Perineural invasion | 0.747 | ||
| Negative | 119(84.4) | 112(83.0) | |
| Positive | 22(15.6) | 23(17.0) | |
| Vascular invasion | 0.296 | ||
| Negative | 92(65.2) | 96(71.1) | |
| Positive | 49(34.8) | 39(28.9) | |
| MS status/MMR status | 0.466 | ||
| MSS/MMR-proficient | 87(61.7) | 89(65.9) | |
| MSI/MMR-deficient | 54(38.3) | 46(34.1) | |
| CEA (ng/ml) | 49.2 ± 14 | 24.2 ± 10 | 0.033 |
TIL indicates tumor infiltrating lymphocytes; MMR indicates mismatch repair; MS, microsatellite; MSS, microsatellite stability; MSI, microsatellite instability.