Table 2.

Univariate and multivariate analysis for overall survival in FUSCC.

Variables	Univariate Analysis			Multivariate Analysis
	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
ITGAE+TIL	0.379	0.237–0.607	<0.001	0.57	0.346–0.938	0.027
Male gender	1.255	0.797–1.976	0.328
Age > 70	1.581	0.915 -2.734	0.101
TNM stage IV	5.118	3.574–7.330	<0.001	4.097	1.739 -9.649	0.001
T stage, T4	10.531	2.580–42.981	0.001	1.632	0.983–2.709	0.058
N stage, N2	4.139	2.332–7.346	<0.001	0.861	0.612–1.212	0.391
Grade, poor	1.36	0.880–2.103	0.166
M1 stage	9.06	5.735–14.314	<0.001	1.254	0.414–3.804	0.689
Lymph node examined	0.72	0.465–1.114	0.14
Mucinous Adenocarcinoma	0.865	0.316 -2.364	0.77
Perineural invasion	1.639	0.980–2.740	0.06
Vascular invasion	2.44	1.578–3.776	<0.001	1.293	0.772–2.164	0.329
MSI	0.923	0.589–1.444	0.725
CEA >10 ng/ml	2.705	1.713–4.273	<0.001	1.004	0.591–1.708	0.987

TIL indicates tumor infiltrating lymphocytes; MMR indicates mismatch repair; MS, microsatellite; MSS, microsatellite stability; MSI, microsatellite instability; LN, lymph nodes.