Table 3.
Univariate and Multivariate analyses of prognostic factors for disease-free survival in FUSCC.
| Univariate Analysis |
Multivariate Analysis |
|||||
|---|---|---|---|---|---|---|
| Variables | Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value |
| ITGAE+TIL | 0.443 | 0.293–0.670 | <0.001 | 0.5491 | 0.355–0.849 | 0.007 |
| Male gender | 1.322 | 0.883–2.009 | 0.172 | |||
| Age > 70 | 1.214 | 0.711–2.072 | 0.478 | |||
| TNM stage IV | 5.363 | 3.837–7.496 | <0.001 | 3.921 | 1.885–8.157 | <0.001 |
| T stage, T4 | 2.401 | 1.630–3.537 | 0.001 | 1.456 | 0.966–2.197 | 0.073 |
| N stage, N2 | 1.886 | 1.498–2.374 | <0.001 | 0.831 | 0.603–1.147 | 0.261 |
| Grade, poor | 1.168 | 0.788–1.730 | 0.439 | |||
| M1 stage | 10.069 | 6.567–15.439 | <0.001 | 1.426 | 0.538–3.777 | 0.476 |
| LN examined >12 | 0.662 | 0.447 0.981 | 0.04 | 0.684 | 0.453–1.032 | 0.07 |
| Mucinous Adenocarcinoma | 0.872 | 0.355–2.144 | 0.765 | |||
| Perineural invasion | 1.892 | 1.203 -2.977 | 0.006 | 1.326 | 0.818–2.149 | 0.252 |
| Vascular invasion | 2.223 | 1.500–3.296 | <0.001 | 0.918 | 0.566–1.489 | 0.729 |
| MSI | 0.946 | 0.631–1.416 | 0.786 | |||
| CEA >10 ng/ml | 3.318 | 2.211 -4.981 | <0.001 | 1.3 | 0.812–2.080 | 0.275 |
TIL indicates tumor infiltrating lymphocytes; MMR, mismatch repair; MS, microsatellite; MSS, microsatellite stability; MSI, microsatellite instability; LN, lymph nodes.