Table 4.

Multivariate cox regression analysis for comparison of outcome measures between case and control cohorts

Outcome	Dose Reduction	HR	95% CI	P Value
Inpatient admission	≥10%	1.17	1.11, 1.23	< 0.001
Inpatient admission	≥30%	1.23	1.17, 1.31	< 0.001
ER visit	≥10%	1.09	1.05, 1.14	< 0.001
ER visit	≥30%	1.14	1.08, 1.19	< 0.001
Schizophrenia admission or ER visit*	≥10%	1.27	1.19, 1.36	< 0.001
Schizophrenia admission or ER visit*	≥30%	1.31	1.21, 1.41	< 0.001
Psychiatric admission or ER visit*	≥10%	1.16	1.10, 1.23	< 0.001
Psychiatric admission or ER visit*	≥30%	1.21	1.14, 1.29	< 0.001
TD claim	≥10%	1.39	0.80, 2.41	0.24
TD claim	≥30%	1.60	0.86, 3.00	0.14

*See Additional file 1: Table S1 for ICD-9 and ICD-10 diagnostic codes

CI confidence interval; ER emergency room; HR hazard ratio; ICD International Classification of Diseases