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Niraparib activates an ATM-AMPK-ULK1-autophagy pathway. Spiky ovarian cancer cells were treated with vehicle control or niraparib (2 μM), for 4h and 8h. Cells were fixed in place and at least forty cells per condition were imaged in independent triplicate and the intensity ratio of phosphorylated protein levels to total protein expression plotted as a percentage of control treatment (n = 3 +/- SD). # p < 0.05 greater than vehicle control; * p < 0.05 less than vehicle control.
