Table 2.
Functional and Pathway Enrichment Analysis of Upregulated and Downregulated Genes in Pancreatic Cancer with the DEGs in the Three mRNA Expression Profiling Datasets
| Term | Description | Count | P Value |
|---|---|---|---|
| Upregulated | |||
| GO:0030198 | integrin-mediated signaling pathway | 21 | 1.05E-14 |
| GO:0030574 | collagen catabolic process | 14 | 6.69E-14 |
| KEGG:hsa04512 | ECM-receptor interaction | 13 | 1.88E-10 |
| GO:0004222 | metalloendopeptidase activity | 12 | 1.65E-08 |
| GO:0030199 | collagen fibril organization | 8 | 1.17E-07 |
| KEGG:hsa04510 | Focal adhesion | 14 | 4.69E-07 |
| KEGG:hsa05146 | Amoebiasis | 10 | 2.82E-06 |
| GO:0005201 | extracellular matrix structural constituent | 8 | 4.49E-06 |
| GO:0004252 | serine-type endopeptidase activity | 13 | 9.59E-06 |
| KEGG:hsa04151 | PI3K-Akt signaling pathway | 15 | 2.96E-05 |
| GO:0005581 | collagen trimer | 8 | 3.05E-05 |
| GO:0031581 | hemidesmosome assembly | 4 | 2.13E-04 |
| KEGG:hsa04974 | protein digestion and absorption | 7 | 4.74E-04 |
| GO:0007229 | integrin-mediated signaling pathway | 7 | 5.24E-04 |
| GO:0005788 | endoplasmic reticulum lumen | 9 | 5.65E-04 |
| GO:0006508 | proteolysis | 15 | 6.11E-04 |
| GO:0007160 | cell-matrix adhesion | 6 | 0.00226 |
| KEGG:hsa05222 | small cell lung cancer | 6 | 0.002763 |
| KEGG:hsa05200 | Pathways in cancer | 12 | 0.004792 |
| GO:0043588 | skin development | 4 | 0.004925 |
| GO:0048333 | mesodermal cell differentiation | 3 | 0.005338 |
| Downregulated | |||
| GO:0003756 | protein disulfide isomerase activity | 3 | 0.001837 |