Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 10;35:334–344. doi: 10.1016/j.ebiom.2018.07.042

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 2 — Filtration of genes with synergetic alterations in DNA methylation and gene expression. (a) Quadrant plot showing DMRs and expression of corresponding genes. The dashed lines indicate a threshold of P value below 0·05. The blue dots signify hypo-methylated and up-regulated genes in RPL, the brown bots signify hypo-methylated and down-regulated genes in RPL, the purple bots signify hyper-methylated and up-regulated genes in RPL and the red bots signify hyper-methylated and down-regulated genes in RPL. (b) Box plots of relative expression level of four genes selected by a threshold of 5% FDR. Error bars, SEM. *P < 0·05, **P < 0·01, ***P < 0·001. Bisulfite sequencing of CREB5 (c) and RBM24 (d). Open and closed circles represent unmethylated and methylated CpG sites and each row corresponds to a single clone sequenced. All loci shown in picture were found to be hypo-methylated in RPL according to the analysis of Infinium Human Methylation 850 K BeadChip data. (e) The expression of CREB5 protein in control group and RPL group.