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. 2018 Aug 10;35:334–344. doi: 10.1016/j.ebiom.2018.07.042

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Functional analysis of CREB5 overexpression in JEG-3 cells. (a) qRT-PCR and western blot was used to detect the expression level of CREB5 mRNA and protein CREB5after transfection. (b) Transwell assay showed that CREB5 overexpression delayed cell migration. Scale bars; 500 μm. (c and d) The result of cell apoptosis indicated that CREB5 overexpression increased significantly the percentage of apoptotic cells. (e and f) Cell counts showed CREB5 overexpression increased significantly S-phase cells and reduced significantly G2/M-phase cells. The data are presented as mean ± SEM. *P < 0·05, **P < 0·01, ***P < 0·001.