Table 2.
Significant RPL-associated differentially methylated regions (DMRs).
| Gene | Region | Probes | Locationa | βb (RPL) | βb (Controls) | FDRc |
|---|---|---|---|---|---|---|
| CREB5 | Chr7:28450001-28,451,011 | cg11093548 | 5'UTR | 0·07 | 0·36 | 0·01 |
| cg22396147 | 5'UTR | 0·09 | 0·28 | 0·001 | ||
| cg14803765 | TSS1500 | 0·08 | 0·31 | 0·008 | ||
| cg14927519 | TSS1500 | 0·17 | 0·33 | 0·03 | ||
| cg01332259 | TSS1500 | 0·06 | 0·25 | 0·003 | ||
| cg17067116 | TSS1500 | 0·04 | 0·27 | 0·03 | ||
| RBM24 | Chr6:17282284–147,282,863 | cg25302957 | TSS1500 | 0·05 | 0·32 | 0·002 |
| cg02685016 | 1stExon | 0·11 | 0·45 | 0·01 | ||
| cg15168816 | TSS1500 | 0·13 | 0·52 | 0·006 | ||
| cg14466942 | TSS1500 | 0·42 | 0·70 | 0·006 | ||
| cg02066331 | TSS200 | 0·48 | 0·69 | 0·02 | ||
| cg02311932 | TSS200 | 0·38 | 0·68 | 0·01 | ||
| cg23146346 | TSS200 | 0·65 | 0·91 | 0·002 | ||
| cg01729060 | 5'UTR | 0·66 | 0·89 | 0·007 | ||
Chr, chromosome;FDR, false discovery rate.
a
Locations of probes in 5’UTR, 1stExon, TSS200 and TSS 1500.
b
Mean CpGs methylation level in RPL and controls measured by Illumina's 850 K Methylation BeadChip.
c
Adjusted P-values by R package ChAMP.