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. 2018 Aug 13;35:142–154. doi: 10.1016/j.ebiom.2018.08.010

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© 2018 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — MiR-590-5p can sensitize ADR-R HCC cells to ADR in vitro and in vivo. (a-b) Relative chemosensitivity of ADR-R HCC cells in the presence or absence of pre-miR-590-5p and anti-miR-590-5p. Cell were treated with 1 μM ADR for 48 h and then subjected to CCK8 analysis (a, n = 5) and caspase-3/7 activity analysis (b, n = 5). Statistical analysis was performed by Student's t-test. (c) The delivery efficiency of miR-590-5p in HCC tumor tissues. (d) The effects of introduction of miR-590-5p on the growth of HCC xenograft derived from Huh7/ADR-R cells (n = 5 for each group). Statistical analysis was performed by Student's t-test. (e) Representative images of IHC staining of Ki67 and cleaved caspase-3 in tumors as shown in panel c. Scale bar: 100 μm. (f) Quantitative analysis of Ki67 and CCS3 staining in xenograft models as shown in panel d (n = 5, ANOVA test). Data were shown as the means ± SD. *, P < .05; **, P < .01; ***, P < .001.