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Proposed models for SRRM4 in driving t-NEPC development through different mechanisms. A schematic diagram illustrates two mechanisms of SRRM4 in driving the development of t-NEPC tumors. AdPC, prostate adenocarcinoma; t-NEPC, treatment-induced neuroendocrine prostate cancer; ARPI, androgen receptor pathway inhibitors; NE, neuroendocrine; LE, luminal epithelial.
