Table 3.

CRF attenuates the effect of age on WMH

Variable	β (SE)	t	p
Age	.009 (.003)	3.48	.001
Sex	−.073 (.035)	−2.07	.041
SBP	.000088 (.001)	0.091	.928
FH	.027 (.033)	0.81	.419
BMI	−.001 (.003)	−0.50	.619
APOE4	−.011 (.031)	−0.34	.732
OUES	−.000043 (.000063)	−0.68	.495
Age × OUES	−.000024 (.0000096)	−2.47	.015

CRF cardiorespiratory fitness, WMH white matter hyperintensities, SE standard error, SBP systolic blood pressure, FH family history of Alzheimer’s disease, BMI body mass index, APOE4 apolipoprotein E ε4 allele carriage, OUES oxygen uptake efficiency slope