Table 1.
List of acceptable chemotherapy regimens
| Cancer type | Regimen and Dosing |
|---|---|
| Bladder cancer |
M-VAC
Interval between cycles: 4 weeks Cisplatin: 70 mg/m2 Doxorubicin: 30 mg/m2 Vinblastine: 3 mg/m2 Methotrexate: 90 mg/m2 |
| Breast cancer |
AC
Interval between cycles: 3 weeks Cyclophosphamide: 600 mg/m2 Doxorubicin: 60 mg/m2 AC → P (sequential regimen) for the P (paclitaxel) cycles Interval between cycles: 3 weeks Paclitaxel: 175 mg/m2 AC → T (sequential regimen) for the T (docetaxel) cycles Variant 1: AC → T Interval between cycles: 4 weeks Docetaxel: 100 mg/m2 Variant 2: AC → T Interval between cycles: 1 week Docetaxel: 35 mg/m2 AV Interval between cycles: 3 weeks Doxorubicin: 50 mg/m2 Vinolrebine: 50 mg/m2 CAPE-T Interval between cycles: 3 weeks Capecitabine: 35000 mg/m2 Docetaxel: 75 mg/m2 CMF Interval between cycles: 4 weeks Cyclophosphamide: 1400 mg/m2 Fluorouracil: 1200 mg/m2 Methotrexate: 80 mg/m2 EC Interval between cycles: 3 weeks Cyclophosphamide: 600 mg/m2 Epidoxorubicin: 100 mg/m2 FEC → T (sequential regimen) for the T (docetaxel) cycles only Interval between cycles: 3 weeks Docetaxel: 100 mg/m2 FEC Interval between cycles: 4 weeks Cyclophosphamide: 1050 mg/m2 Epirubicin: 120 mg/m2 Fluorouracil: 1000 mg/m2 P Interval between cycles: 3 weeks Paclitaxel: 250 mg/m2 EC → T (sequential regimen) for the T (docetaxel) cycles Interval between cycles: 3 weeks Docetaxel: 100 mg/m2 T Interval between cycles: 3 weeks Docetaxel: 100 mg/m2 TC Interval between cycles: 3 weeks Cyclophosphamide: 600 mg/m2 Docetaxel: 75 mg/m2 |
| Cervical cancer |
CDDP/PACLI
Interval between cycles: 3 weeks Cisplatin: 50─75 mg/m2 Paclitaxel: 135 mg/m2 CDDP/TOPOTECAN Interval between cycles: 3 weeks Cisplatin: 50 mg/m2 Topotecan: 2.25 mg/m2 IRINOTECAN Interval between cycles: 6 weeks Irinotecan: 500 mg/m2 TOPOTECAN Interval between cycles: 4 weeks Topotecan: 7.5 mg/m2 |
| Colorectal cancer |
5FU/LEUCO
Interval between cycles: 4 weeks Fluorouracil: 2125 mg/m2 Leucovorin: 100 mg/m2 FOLFIRI Variant 1: FOLFIRI Interval between cycles: 2 weeks Fluorouracil: 2000─2400 mg/m2 Irinotecan: 180 mg/m2 Leucovorin: 200─400 mg/m2 Variant 2: FOLFIRI Interval between cycles: 1 week Fluorouracil: 2300 mg/m2 Irinotecan: 80 mg/m2 Variant 3: FOLFIRI Interval between cycles: 2 weeks Fluorouracil: 2000 mg/m2 Irinotecan: 180 mg/m2 FOLFOX Interval between cycles: 2 weeks Fluorouracil: 1600 mg/m2 Leucovorin: 200 mg/m2 Oxaliplatin: 85 mg/m2 |
| Gastric cancer |
CDDP/IRINO
Interval between cycles: 3 weeks Cisplatin: 60 mg/m2 Irinotecan: 130 mg/m2 DOCE/IRINO Interval between cycles: 3 weeks Docetaxel: 30 mg/m2 Irinotecan: 140 mg/m2 ECF Interval between cycles: 3 weeks Epirubicin: 50 mg/m2 Cisplatin: 60 mg/m2 Fluorouracil: 200 mg/m2 ECX Interval between cycles: 3 weeks Epirubicin: 50 mg/m2 Cisplatin: 60 mg/m2 Capecitabin: 26250 mg/m2 EOF Interval between cycles: 3 weeks Epirubicin: 50 mg/m2 Oxaliplatin: 130 mg/m2 Fluorouracil: 200 mg/m2 EOX Interval between cycles: 3 weeks Epirubicin: 50 mg/m2 Oxaliplatin: 130 mg/m2 Capecitabine: 26250 mg/m2 FOLFOX Interval between cycles: 2 weeks Fluorouracil: 3400 mg/m2 Oxaliplatin: 100 mg/m2 |
| Germ cell tumors |
BEP followed by EP
Interval between cycles: 3 weeks Bleomycin: 90 U Cisplatin: 100 mg/m2 Etoposide: 500 mg/m2 CDDP/VP16 Interval between cycles: 3 weeks Cisplatin: 100 mg/m2 Etoposide: 300─500 mg/m2 |
| Hodgkin lymphoma |
Stanford V
Interval between cycles: 4 weeks Bleomycin: 10 U Doxorubicin: 50 mg/m2 Etoposide: 120 mg/m2 Mechlorethamine: 6 mg/m2 Vinblastine: 12 mg/m2 Vincristine: 2.8 mg/m2 |
| Non-Hodgkin lymphoma |
ACOD
Interval between cycles: 3 weeks Cyclophosphamide: 1000 mg/m2 Doxorubicin: 50 mg/m2 Vincristine: 2.4 mg/m2 CCOP Interval between cycles: 4 weeks Cyclophosphamide: 750 mg/m2 Liposomal Doxorubicin: 30 mg/m2 Vincristine: 2 mg/m2 CHOP Interval between cycles: 2 or 3 weeks Cyclophosphamide: 750–1200 mg/m2 Doxorubicin: 50–75 mg/m2 Vincristine: 1.4 mg/m2 DA-EPOCH Interval between cycles: 3 weeks Cyclophosphamide: 3750 mg/m2 Doxorubicin: 40 mg/m2 Etoposide: 200 mg/m2 Vincristine: 1.6 mg/m2 GMOX-R (with rituximab) Interval between cycles: 2 or 3 weeks Gemcitabine: 1000 mg/m2 Oxaliplatine: 100 mg/m2 GC Variant 1: Interval between cycles: 4 weeks Cisplatin: 100 mg/m2 Gemcitabine: 3000 mg/m2 Variant 2: Interval between cycles: 3 weeks Cisplatin: 75 mg/m2 Gemcitabine: 2000 mg/m2 MEGACHOP (with rituximab) Interval between cycles: 3 weeks Cyclophosphamide: 1200 mg/m2 Doxorubicin: 75 mg/m2 Vincristine: 2 mg/m2 RFM (with rituximab) Interval between cycles: 4 weeks Fludarabine: 75 mg/m2 Mitoxantrone: 10 mg/m2 |
| Non-small cell lung cancer |
Carbo/PACLI
Interval between cycles: 3 weeks Carboplatin: 6 AUC Paclitaxel: 200 mg/m2 CDDP/DOCE Interval between cycles: 3 weeks Cisplatin: 75 mg/m2 Docetaxel: 75 mg/m2 CDDP/PACLI Interval between cycles: 3 weeks Cisplatin: 50─75 mg/m2 Paclitaxel: 135 mg/m2 CDDP/VNR Variant 1: CDDP/VNR Interval between cycles: 4 weeks Cisplatin: 100 mg/m2 Vinorelbine: 100 mg/m2 Variant 2: CDDP/VNR Interval between cycles: 4 weeks Cisplatin: 100 mg/m2 Vinorelbine: 120 mg/m2 CDDP/VP16 Interval between cycles: 3 weeks Cisplatin: 100 mg/m2 Etoposide: 300─500 mg/m2 VIG Variant 1: VIG Interval between cycles: 3 weeks Gemcitabine: 1800 mg/m2 Ifosfamide: 3000 mg/m2 Navelbine: 45 mg/m2 Variant 2: VIG Interval between cycles: 3 weeks Gemcitabine: 2000 mg/m2 Ifosfamide: 3000 mg/m2 Navelbine: 50 mg/m2 T Interval between cycles: 3 weeks Docetaxel: 75 mg/m2 |
| Occult primary adenocarcinoma |
DOCE/GEMCI
Interval between cycles: 3 weeks Docetaxel: 75 mg/m2 Gemcitabine: 2000 mg/m2 |
| Esophageal cancer |
CDDP/IRINO
Interval between cycles: 3 weeks Cisplatin: 60 mg/m2 Irinotecan: 130 mg/m2 ECF Interval between cycles: 3 weeks Epirubicin: 50 mg/m2 Cisplatin: 60 mg/m2 Fluorouracil: 200 mg/m2 ECX Interval between cycles: 3 weeks Epirubicin: 50 mg/m2 Cisplatin: 60 mg/m2 Capecitabin: 26250 mg/m2 EOF Interval between cycles: 3 weeks Epirubicin: 50 mg/m2 Oxaliplatin: 130 mg/m2 Fluorouracil: 200 mg/m2 EOX Interval between cycles: 3 weeks Epirubicin: 50 mg/m2 Oxaliplatin: 130 mg/m2 Capecitabine: 26250 mg/m2 |
| Ovarian cancer |
CARBO/DOCE
Interval between cycles: 3 weeks Carboplatin: 5 AUC Docetaxel: 75 mg/m2 CARBO/PLACLI → TOPOTECAN (sequential treatment) only for the topotecan cycles Interval between cycles: 3 weeks Topotecan: 7.5 mg/m2 TOPOTECAN Interval between cycles: 3 weeks Topotecan: 7.5 mg/m2 |
| Pancreatic cancer |
GEMCI/IRINO
Interval between cycles: 3 weeks Gemcitabine: 2000 mg/m2 Irinotecan: 300 mg/m2 |
| Prostate cancer |
CABAZITAXEL
Interval between cycles: 3 weeks Cabazitaxel: 25 mg/m2 T Interval between cycles: 3 weeks Docetaxel: 75─100 mg/m2 |
| Small-cell lung cancer |
CARBO/VP16
Interval between cycles: 3 weeks Carboplatin: 300 mg/m2 Etoposide: 900 mg/m2 CAV Interval between cycles: 3 weeks Cyclophosphamide: 750 mg/m2 Doxorubicin: 40 mg/m2 Vincristine: 1.3 mg/m2 CDE Interval between cycles: 3 weeks Cyclophosphamide: 1000 mg/m2 Doxorubicin: 45 mg/m2 Etoposide: 300 mg/m2 CDDP/VP16 Interval between cycles: 3 weeks Cisplatin: 100 mg/m2 Etoposide: 300─500 mg/m2 |
| Soft tissue sarcoma |
T
Interval between cycles: 3 weeks Docetaxel: 100 mg/m2 |
| Uterine cancer |
T
Interval between cycles: 3 weeks Docetaxel: 100 mg/m2 |