Table 2.
The CD204 positive cell population percentages are shown in patients with (SSc-ILD) or without interstitial lung disease (SSc-No ILD) at lung CT scan and healthy subjects (HSs)
| Analysis of circulating CD204+ cells | SSc-ILD (37) | SSc-No-ILD (18) | p (MW) | HSs (27) | p (KW) |
|---|---|---|---|---|---|
| CD204+ (%) | 0.5 ± 0.40 | 0.8 ± 0.7 | p = 0.13 | 0.7 ± 0.3 | 0.21 |
| CD204+CD163+ (%leukocytes) | 0.08 ± 0.22 | 0.09 ± 0.14 | p = 0.65 | 0.03 ± 0.03 | 0.001 |
| CD204+CD163+ (%CD204+) | 13.7 ± 15 | 8.4 ± 13 | p = 0.034 | 6.3 ± 3 | < 0.0001 |
| CD204+CD163+TLR4+ (%leukocytes) | 0.03 ± 0.22 | 0.02 ± 0.15 | p = 0.34 | 0.008 ± 0.01 | < 0.0001 |
| CD204+CD163+TLR4+ (%CD204+) | 6.2 ± 16 | 2.9 ± 15 | p = 0.025 | 1.4 ± 1.7 | < 0.0001 |
| CD204+CD163+CD206+ (%leukocytes) | 0.01 ± 0.1 | 0.01 ± 0.05 | p = 0.65 | 0.008 ± 0.01 | 0.001 |
| CD204+CD163+CD206+ (%CD204+) | 4 ± 7.4 | 1.9 ± 5.6 | p = 0.07 | 1.1 ± 1.2 | < 0.0001 |
| CD204+CD163+CD206+TLR4+ (%leukocytes) | 0.014 ± 0.1 | 0.11 ± 0.05 | p = 0.20 | 0.003 ± 0.004 | < 0.0001 |
| CD204+CD163+CD206+TLR4+ (%CD204+) | 2.7 ± 7.3 | 1.1 ± 5.9 | p = 0.013 | 0.5 ± 0.6 | < 0.0001 |
| CD204+CD163+CD206+ TLR4+CD14+(%leukocytes) | 0.003 ± 0.014 | 0.004 ± 0.003 | p = 0.795 | 0.001 ± 0.003 | 0.008 |
| CD204+CD163+CD206+ TLR4+CD14+(%CD204+) | 0.73 ± 1.4 | 0.27 ± 0.54 | p = 0.097 | 0.20 ± 0.38 | < 0.0001 |
| CD204+CD163+CD206+ TLR4+CD14− (%leukocytes) | 0.009 ± 0.08 | 0.006 ± 0.05 | p = 0.092 | 0.001 ± 0.002 | < 0.0001 |
| CD204+CD163+CD206+ TLR4+CD14− (%CD204+) | 1.93 ± 6.56 | 0.6 ± 5.69 | p = 0.029 | 0.17 ± 0.41 | < 0.0001 |
| CD204+CD163+CD206+ TLR4+CD80+ (%leukocytes) | 0.01 ± 0.09 | 0.004 ± 0.05 | p = 0.041 | 0.001 ± 0.003 | < 0.0001 |
| CD204+CD163+CD206+ TLR4+CD80+ (%CD204+) | 2.07 ± 6.83 | 0.5 ± 5.33 | p = 0.010 | 0.16 ± 0.48 | < 0.0001 |
| CD204+CD163+CD206+ TLR4+CD86+ (%leukocytes) | 0.008 ± 0.08 | 0.005 ± 0.04 | p = 0.082 | 0.001 ± 0.002 | < 0.0001 |
| CD204+CD163+CD206+TLR4+ CD86+ (%CD204+) | 1.16 ± 5.8 | 0.72 ± 4.1 | p = 0.023 | 0.19 ± 0.36 | < 0.0001 |
| CD204+CD163+CD206+TLR4+ CD80+CD86+ (%leukocytes) | 0.04 ± 0.08 | 0.002 ± 0.03 | p = 0.036 | 0.0006 ± 0.001 | < 0.0001 |
| CD204+CD163+CD206+TLR4+ CD80+CD86+ (%CD204+) | 1 ± 5.6 | 0.39 ± 4 | p = 0.021 | 0.08 ± 0.2 | < 0.0001 |
By Mann-Whitney test, several mixed M1/M2 cell populations were found to show significantly higher percentages (p MW highlighted in bold) in SSc patients affected by ILD, compared to SSc patients with no ILD. On the right, Kruskal-Wallis test was performed adding HSs data, obtaining more significant results (p KW)