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. 2018 Sep 21;8:14212. doi: 10.1038/s41598-018-32616-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Humanin treatment reduces Aβ-induced toxicity (A) SH-SY5Y cells treated with Aβ (2 µM) have a decrease in viability measured by MTT and this is prevented by HNG treatment (B) or when measured by calcein stain (C) Isolated neuronal mitochondria increase ROS production upon Aβ treatment and HNG treatment prevents this induction. * indicates p < 0.05.