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. 2018 Sep 21;8:14191. doi: 10.1038/s41598-018-32578-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RT of GIC-driven orthotopic tumors. (A) 4–5 weeks old NOD-SCID mice were stereotactically injected in the left corpus striatum with 2–5 × 10⁵ COMI GIC. 50 days later, mice were i.c.-administered with vehicle (2.5% ethanol in 0.9% NaCl) and then irradiated with one (total: 2.5 Gy), three (total: 7.5 Gy), four (total: 10.0 Gy) or five (total: 12.5 Gy) 2.5 Gy fractions to the head. Increased survival was observed up to the 10.0 Gy cumulative IR dose. Additional 2.5 Gy (cumulating to a total of 12. 5 Gy) were rapidly lethal with all mice dying in 24–48 hours (solid line). Differences between survival curves with P < 0.05, 0.01, 0.001 are indicated with one, two and three asterisks, respectively. (B) For comparison, the heads of tumor-free wild type C57Black mice (left) were irradiated every weekday with 2.5 Gy over five weeks (total dose delivered: 62.5 Gy). Blood samples were then drawn for hematology and the brains explanted for histopathology. No significant variation of (C) animal survival; (D) hematocrit; (E) hemoglobin; (F) normal brain histology was observed in irradiated (IR) versus unirradiated (C) mice.