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. 2018 Sep 21;8:14228. doi: 10.1038/s41598-018-32591-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sequence alignment of ALASs from various species. The amino acid sequence of ALAS from C. crescentus was compared with human ALAS1 (non-specific housekeeping isozyme), human ALAS2 (erythroid-specific isozyme), Sphingomonas WHSC8 (S.WHSC8) ALAS, and R. capsulatus ALAS. The alignment was performed with Genetyx (Software Development Co., Fukuoka, Japan) and ESPript⁵⁸. The lysine residues predicted to bind PLP are highlighted in yellow and marked with circles, and the residues identified as the heme axial ligands of C. crescentus ALAS are highlighted in green and marked with triangles. The N-terminal extending regions of 186 and 133 residues containing the presequence for human ALAS1 and ALAS2, respectively, are omitted.