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. 2018 Sep 21;8:14164. doi: 10.1038/s41598-018-32589-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Systemic levels of LTB4 and cytokines in diabetic 5LO^−/− or WT mice. Plasma was collected from WT or 5LO^−/− mice, healthy or diabetic (T1D), for LTB4 dosage by ELISA (A). Serum from mice was collected for cytokine dosage by CBA: TNF-α (B), IL-6 (C), IL-10 (D) IL-12p70 (E) and IFN-γ (F). Data are presented as the mean ± SEM of 4 to 6 animals per group. *p ≤ 0.05 when diabetic groups were compared to healthy WT, and ^#p ≤ 0.05 when diabetic 5LO^−/− mice were compared to diabetic WT. ULD = under the limit of detection.