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. 2018 Sep 21;8:14172. doi: 10.1038/s41598-018-32474-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Propofol exposure results in the dysregulated mRNA profiles in P7 mouse hippocampi. (A) Scatter plot displaying that the overall mRNA transcriptome is similar between intralipid- and propofol-treated mouse hippocampal samples. (B) The volcano plot illustrating the differentially expressed mRNAs (red dots) between control and propofol groups. All mRNAs profiled were represented as points in the scatter plot with fold change and p value on the x and y axis, respectively. These altered mRNAs were either downregulated (left red dots) or upregulated (right red dots) following propofol exposure. (C) Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) validation of propofol-induced changed mRNAs with top 3 highest up-regulated and top 3 down-regulated (including Olig3, Npas4, Egr4, Cldn8, Vmn2r116 and Gm597) according to the microarray assay. n = 4; *p < 0.05.