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. 2018 Sep 21;8:14172. doi: 10.1038/s41598-018-32474-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Propofol induces the dysregulation of miRNA profiles in 7-day-old mouse hippocampi. (A) Expression profile of altered miRNAs detected using RT-qPCR. miRNA expression in the propofol-treated group is expressed as percent of intralipid controls. (B) Heatmap showing the profiles of 18 differentially expressed miRNAs between intralipid and propofol-treated mouse hippocampi. The red, green, and black signals refer to the relatively higher, lower, and baseline levels of miRNA expression compared with the control group, respectively. Expression level of each sample for individual miRNAs was displayed as percentage of the control average. n = 4; p < 0.05.