Table 2.
The propofol-induced acute dysregulated miRNA-mediated mRNA signaling that potentially participate in propofol-induced developmental neurotoxicity in P7 mice.
| Target mRNAs | miRNAs | Possible neurodegeneration-related pathways |
|---|---|---|
| NPAS4 | miR-378a-3p | Apoptosis, Necrosis |
| ARHGEF6 | miR-882 | Apoptosis, Cell Migration, Necrosis |
| CYSLTR1 | miR-98/882 | Apoptosis, Cell Injury, Cell Migration, Necrosis, Release of Ca2+, Thickening of Brain Septum |
| LDLR | miR-106b/882 | Apoptosis, Abnormal Morphology of Astrocytes/Cerebellum/Nerve Ending, Cellular Migration, Necrosis, Quantity of Reactive Oxygen Species |
| SPRED3 | miR-98/432 | Unknown |
| SMIM3 | miR-98/344f-3p | Unknown |
| TXNIP | miR-106b/384-3p/665 | Apoptosis, Cell Injury, Necrosis, Quantity of Reactive Oxygen Species |
| PLEKHF1 | miR-882 | Apoptosis, Necrosis |
| C8orf4 | miR-432 | Apoptosis, Necrosis |
| AGBL3 | miR-200c | Unknown |
| KCTD14 | miR-98/432 | Unknown |
| MALL | miR-882 | Unknown |
| HBP1 | miR-106b | Unknown |
| HTRA4 | miR-98 | Unknown |
| OTOGL | miR-200c | Unknown |
| ITK | miR-432 | Apoptosis, Cellular Migration, Necrosis, Release of Ca2+ |
| C19orf54 | miR-98 | Unknown |
| MESP1 | miR-344f-3p | Cell Migration, Development of Neuroectoderm, Migration of Stem Cell |
| CDH19 | miR-384-3p | Unknown |
| HAO1 | miR-665 | Cell Migration |
| SLC5A8 | miR-378a-3p | Apoptosis, Necrosis |
| LIF | miR-106b/378a-3p/882 | Apoptosis, Abnormal Morphology of Cerebellum/Astrocytes, Cellular Migration, Expansion of Neural Stem Cells, Growth of Axon, Induction of Astrocyte/Neurons, Myelination of Oligodendrocytes, Necrosis, Neurogenesis of Neural Stem Cells, Proliferation of Neural Stem Cells, Quantity of Neural Stem Cells/Reactive Oxygen Species, Release of Ca2+ |
| ADCY10 | miR-882 | Apoptosis, Cell Migration, Growth of Axon, Necrosis |
| TMPRSS2 | miR-98/665 | Unknown |