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. 2018 Sep 21;9:3860. doi: 10.1038/s41467-018-06192-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Organisation of the holo-Imp-L2 dimer in complexes with DILP5 and IGF-1. Only DILP5 complex is shown as a representative example. Each individual Imp-L2 molecule is in white and yellow, DILP5 B-chain in green and A-chain in blue. a The general arrangement of the holo-dimer in a view similar to as in Fig. 3a and 4a. b A close-up on the inter-monomer interface in holo-dimer after ~90° rotation along horizontal axis of the dimer shown in a. c A close-up on the inter-monomer interface in holo-dimer after 90° rotation along vertical axis of the dimer shown in a. The 70–92 loops of each dimer shown in Van der Waals spheres, and coloured correspondingly to their monomers