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. 2018 Sep 21;8:14223. doi: 10.1038/s41598-018-31773-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunodetection of misSOD1 accumulation in spinal cord of A4V SOD1 FALS patient Lumbar spinal cord sections from A4V-SOD1 FALS autopsied patient (positive control) and non-neurological control individual (negative control) immunostained with 5 misSOD1 conformational antibodies (4–20Ra, 24–39Ra, 57–72Ra, C4F6 and 131–153 R). Characteristic misSOD1-positive cytoplasmic accumulation in spinal motor neurons can be observed with all tested antibodies in the A4V-SOD1 FALS patient, whereas no immunostaining is detected in the non-neurological control. Scale bar: 50 mm.