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. 2018 Sep 21;8:14223. doi: 10.1038/s41598-018-31773-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of misSOD1-positive ring-like structure in the SALS and control individuals Representative images of misSOD1-positive ring-like structures in the extracellular space. (A–D) misSOD1-positive serpiginous structures detected in SALS cases detected in spinal horn grey matter. (E–G) misSOD1-negative CA-like structures detected in SALS cases located in the spinal cord tissue section periphery. (H) Spinal ventral horn grey matter accumulation of misSOD1-positive CA-like structures and, peripheral white matter negative misSOD1 CA-like deposits within the spinal cord.