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. 2018 Sep 24;8:14244. doi: 10.1038/s41598-018-32652-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of EMC2-RSPO2 fusion gene expression in HEK293 cells. (a) Western Blot assay of LGR5 protein in HEK293 and LoVo cells. (b) WNT/β-catenin pathway activities in HEK293- TCF cells transfected with pcDNA-R2, pcDNA-ER2 and pcDNA3.1 plasmid. (c) β-catenin expression by q-PCR detection in HEK293 after transfection of pcDNA-R2, pcDNA-ER2 and pcDNA3.1. (d) RSPO2 protein expression in HEK293 after transfection of pcDNA-R2, pcDNA-ER2 and pcDNA3. (e) Cell proliferation curves of HEK293 stably transfected by plasmid pcDNA-R2, pcDNA-ER2 and pcDNA3. (f) Tumor growth curves by the HEK293-pER2, HEK293-pR2, HEK293-pcDNA3.1 induced by implanting 5×10⁶ cells in nude mice. Mice number N = 10. *p < 0.05, **p < 0.01, ***p < 0.001.