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. 2018 Sep 24;8:14244. doi: 10.1038/s41598-018-32652-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RSPO2 fusion PDX tumor growth inhibition by CGX1321. (a) GA3055, CR3056, GA007 and GA108 PDX xenograft mouse models were treated with 1 ml/kg vehicle formulation or 1 mg/kg CGX1321, p.o., QD for 21, 25 and 28 days respectively (N = 6). (b) Axin2 mRNA levels detected by quantitative RT-PCR 7 hours after final dosing (N = 4), **p < 0.01, ***p < 0.001. (c) Alcian blue staining of the vehicle and treated GA007 tumor samples. GA007 PDX xenograft mouse models were treated with 1 ml/kg vehicle formulation or 1 mg/kg CGX1321 for 27 days. left: vehicle group; right: treatment group. Scale bar is 50 μm.