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. 2018 Sep 24;8:14238. doi: 10.1038/s41598-018-32654-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Body weights in the irradiated group, normalized to baseline, were significantly lower than sham at day 3 (t₅₀ = 10.2, p < 10⁻¹³) and day 10 (t₁₄₈ = 8.39, p < 10⁻¹³), but not at day 17 (t₁₅ = 1.60, p = 0.12). Error bars are 95% confidence intervals. (B) A post-irradiation decrease in body weight significantly correlated with the time active on running wheels on the four days immediately after irradiation for the irradiated group (top, r = 0.31, p = 0.005, n = 81) but not the sham group (bottom, r = 0.18, p = 0.161, n = 63).