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. 2018 Sep 24;8:14299. doi: 10.1038/s41598-018-32653-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of SUM159 dissemination to bone. (a) Representative H&E images of the tibia from a SUM159-inoculated mouse (n = 8 mice). Left panel = 4X, right panel = 20X of the same tibia. Scale bars = 500 μM (left panel) and 100 μM (right panel). (b) Histomorphometric analysis of bone volume/total volume (%BV/TV) from mice described in (a). (c) Representative microCT images of non-tumor-inoculated (naïve) mice (n = 10 mice) and SUM159-inoculated mice (n = 8 mice). (d) micro-CT analysis of mice described in (c). (e) qPCR of whole bone homogenate from mice described in (c) for human B2M or human HPRT1 normalized to mouse Hmbs (housekeeping gene). (e) Mann-Whitney U-test, *P < 0.05.