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. 2018 Sep 24;8:14299. doi: 10.1038/s41598-018-32653-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of method efficiency in detecting tumor cells in the bone by model. Check mark indicates positive detection of tumor cells in the bone by the indicated method. N.D. indicates no detectable tumor cells by the given method, despite the use of appropriate positive and negative controls. Question mark indicates the lack of a specific tumor cell marker to detect tumor cells in the bone by the indicated method.