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. 2018 Sep 24;9(10):974. doi: 10.1038/s41419-018-1010-2

Fig. 7. Schematic diagram shows that tumor-derived CCL19 combines with CCR7 expressed by endothelial cells and suppresses CRC angiogenesis.

Fig. 7

The function of CCL19 on angiogenesis is through inducing miR-206 thus inhibiting Met/ERK/Elk-1/HIF-1α/VEGF-A pathway, which can promote the proliferation, migration, and tube formation of ECs