Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Mar 8;22(3):426. doi: 10.3390/molecules22030426

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Binding of the NADP⁺ cofactor (ball and sticks, green carbon atoms) and compounds 1 (ball and sticks, yellow carbon atoms) in the active site of: (A) TbPTR1 (grey ribbons); and (B) LmPTR1 (pink ribbons). Binding of the NADP⁺ cofactor (ball and sticks, green carbon atoms) and compound 3 (ball and sticks, purple carbon atoms) in the active site of: (C) LmPTR1 subunit C, and (D) LmPTR1 subunit A. The 2Fo−Fc electron density maps corresponding to the inhibitors (dark-blue wire) and NADP⁺ (light-blue wire), contoured at the 1σ level, are shown. H-bonds involving the cofactor and inhibitor are shown as dashed lines. It is worth noting the different orientation and environment of the compound 3 catechol ring between subunits C and A of LmPTR1.

Binding of the NADP⁺ cofactor (ball and sticks, green carbon atoms) and compounds 1 (ball and sticks, yellow carbon atoms) in the active site of: (A) TbPTR1 (grey ribbons); and (B) LmPTR1 (pink ribbons). Binding of the NADP⁺ cofactor (ball and sticks, green carbon atoms) and compound 3 (ball and sticks, purple carbon atoms) in the active site of: (C) LmPTR1 subunit C, and (D) LmPTR1 subunit A. The 2Fo−Fc electron density maps corresponding to the inhibitors (dark-blue wire) and NADP⁺ (light-blue wire), contoured at the 1σ level, are shown. H-bonds involving the cofactor and inhibitor are shown as dashed lines. It is worth noting the different orientation and environment of the compound 3 catechol ring between subunits C and A of LmPTR1.