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. 2017 Mar 8;22(3):426. doi: 10.3390/molecules22030426

Table 1.

IC50 values of compounds 13 and 1A3A against Trypanosoma brucei pteridine reductase 1 (TbPTR1) and Leishmania major pteridine reductase 1 (LmPTR1). Standard deviations agreed to ±10%. NI: No Inhibition. The percentage of inhibition at 50 μM is reported in Table S1 of the Supporting Information. The control compound was pyrimethamine, a PTR1 inhibitor (100% inhibition at 50 μM against both PTR1 enzymes). NI = No Inhibition (percentage of inhibition lower than 15%).

Compound IC50 TbPTR1 (μM) IC50 LmPTR1 (μM)
1 31.0 57.0
2 133.0 35.0
3 82.0 36.0
1A 4.3 12.5
2A NI at 50 μM NI at 50 μM
3A 38.0 35.0