Table 2.
The optimal 26 features for identifying hot spots based on the two-step feature selection method.
| Rank | Feature name | Symbol | F-score | Feature type |
|---|---|---|---|---|
| 1 | Weighted Solvent exposure features (HSEAU) | W_HSEAU | 0.9346 | Site |
| 2 | Weighted Solvent exposure features (HSEBU) in Euclidean neighborhood | W_HSEBU_EN | 0.7007 | Euclidian |
| 3 | Weighted normalized residue contacts in complex in Euclidean neighborhood | W_Ncrc_EN | 0.6894 | Euclidian |
| 4 | Weighted Side-chain environment (pKa_1) | W_Pka1 | 0.6737 | Site |
| 5 | Weighted Disorder_6 score in Voronoi neighborhood | W_Disorder6_VN | 0.6546 | Voronoi |
| 6 | Δ(delta) normalized residue contacts | Delncr | 0.6086 | Site |
| 7 | Pair potentials in monomer | Ppm | 0.3576 | Site |
| 8 | Weighted Blosum (A) in Voronoi neighborhood | W_BlosumA_VN | 0.2991 | Voronoi |
| 9 | Weighted Blosum (T) | W_BlosumT | 0.2258 | Site |
| 10 | Weighted Sidechain energy score | W_SCE1 | 0.1991 | Voronoi |
| 11 | Side chain energy score (SCE-score (conserv)) | SCE4 | 0.1842 | Site |
| 12 | Weighted Second Structure (SS) helix in Voronoi neighborhood | W_SS1_VN | 0.1716 | Voronoi |
| 13 | Second Structure (SS) coil in Voronoi neighborhood | SS3_VN | 0.1675 | Voronoi |
| 14 | Weighted Disorder_4 score | W_Disorder4 | 0.1502 | Site |
| 15 | SCE-score (conbine_1) in Euclidean neighborhood | SCE5_EN | 0.13108 | Euclidian |
| 16 | PSSM (Q) | PssmQ | 0.1261 | Site |
| 17 | Hydrogen bonds in Euclidean neighborhood | Hb_EN | 0.1163 | Euclidian |
| 18 | Weighted PSSM (H) | W_PssmH | 0.1117 | Site |
| 19 | Blosum (W) | BlosumW | 0.1078 | Site |
| 20 | Weighted Disorder_5 score | W_Disorder5 | 0.0502 | Site |
| 21 | Weighted SCE-score (conbine_1) in Euclidean neighborhood | W_SCE5_EN | 0.02217 | Euclidian |
| 22 | Disorder_6 score | Disorder6 | 0.01865 | Site |
| 23 | Weighted PSSM (C) in Voronoi neighborhood | W_PssmC_VN | 0.01427 | Voronoi |
| 24 | Physicochemical properties (polarity) in Euclidean neighborhood | polarity_EN | 0.001 | Euclidian |
| 25 | PSSM (V) in Voronoi neighborhood | PssmV_VN | 0.00069 | Voronoi |
| 26 | Blosum (F) in Voronoi neighborhood | BlosumF_VN | 0.00018 | Voronoi |