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. 2018 Sep 24;8:14294. doi: 10.1038/s41598-018-32428-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Oral treatment with FKA blocks osteosarcoma lung metastasis in vivo. (A) Experimental design. (B,D) FKA treatment significantly reduced the number of metastatic surface lung nodules. (C) Mean normalized lung weight (LW) to body weight (BW) was significantly lower in the FKA-treated group compared to the FKA-treated group. (E) Western blot showing Skp2 protein expression in two representative lung specimens harvested from control and FKA-treated mice. Skp2 expression in lung tissue lysates was markedly suppressed after FKA treatment (F) Representative pictures of HE and IHC staining of lung tissues. Independent t-tests were used to compare differences in the LW/BW ratio and lung nodules between control and FKA-treated groups. Statistical significance is indicated by: *p < 0.05, **p < 0.01, ***p < 0.001. Column: mean; Error bars: SD.