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. 2018 Sep 24;9(10):987. doi: 10.1038/s41419-018-1001-3

Fig. 1. Hepcidin is upregulated in TC cells and modulates the levels of iron.

Fig. 1

a The secretion of hepcidin in TC patients (n = 48) and healthy participants (n = 38). b The secretion of hepcidin in the Nthy-ori 3-1 cells and TC cells (K1, BCPAP, TPC1, and 8505C). c Upper, the western blot of ferroportin (FPN) in indicated thyroid cells; lower, the relative density of western blot was analyzed by Image J software. d The intracellular labile iron contents in indicated thyroid cells. e The expression of FPN in K1 and 8505C cells after treatment of control antibody or antibody of hepcidin (3 µg/ml). f The intracellular labile iron contents in K1 and 8505C cells after treatment of control antibody or antibody of hepcidin (3 µg/ml). g The proliferation of K1 and 8505C cells after treatment of control antibody or antibody of hepcidin (2 µg/ml, L; 3 µg/ml, h) was analyzed by MTT assay. h BrdU analysis of K1 and 8505C cells proliferation after treatment of control antibody or antibody of hepcidin (2 µg/ml, L; 3 µg/ml, h). Each experiment was repeated for three times. *P < 0.05, **P < 0.01