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. 2018 Sep 24;8:14272. doi: 10.1038/s41598-018-32690-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MyD88-dependent AS manifestation and lymphocyte abnormalities in B6/lpr mice. (a) SLOs and SGs extracted from 24-week-old female Myd88^+/+ and Myd88^−/− B6/lpr mice. Representative spleen (left picture) and SMGs with SGALNs (right picture) for each genotype are shown. (b) Representative areas of H&E-stained sections of SGs from Myd88^+/+ (left) and Myd88^−/− (right) B6/lpr mice. Original magnification: ×20. (c) Pathological scores of SG sections evaluated from eight mice per genotype. Results are expressed as mean ± SD calculated from mean scores of four sections per animal. *p < 0.01. (d) Total number of CD3⁺, B220⁺, and CD3⁻B220⁻ cells collected from spleen (left graph) and SGALN (right graph) from Myd88^+/+ and Myd88^−/− B6/lpr mice was calculated using flow cytometry. Similar results were obtained from all four animals for each strain, therefore a representative result is shown. (e) Flow cytometric analysis of CD3⁺ T cells from spleen (upper) and SGALN (lower) of Myd88^+/+ and Myd88^−/− B6/lpr mice. Representative plots for CD4/CD8 expression from three separate experiments are shown.