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. 2018 Sep 24;8:14272. doi: 10.1038/s41598-018-32690-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MyD88-dependent AS manifestation in NOD mice. (a) Total number of CD3⁺, B220⁺, and CD3⁻B220⁻ cells collected from spleen (left graph) and SGALN (right graph) of 12-week-old female Myd88^+/+ and Myd88^−/− NOD mice were calculated using flow cytometry. Similar results were obtained from all four animals for each strain, therefore a representative result is shown. (b) Flow cytometric analysis of CD3⁺ T cells from spleen (upper) and SGALN (lower) of Myd88^+/+ and Myd88^−/− NOD mice. Representative plots for CD4/CD8 expression of four separate experiments are shown. (c) Representative H&E-stained sections of whole SG from Myd88^+/+ (left) and Myd88^−/− (right) NOD mice. Original magnification: ×1.5. (d) Representative areas of H&E-stained sections of SGs from Myd88^+/+ (left) and Myd88^−/− (right) NOD mice. Original magnification: ×10. (e) Number of foci in SG sections evaluated from fifteen mice per genotype. Results are expressed as mean ± SD (bar graph) of mean values of total foci numbers of four SG sections per animal (circle point). *p < 0.01. (f) Percentage of total area of foci in SG sections evaluated from fifteen mice per genotype. Results are expressed as mean ± SD (bar graph) of mean values of percentage of total foci area of four SG sections per animal (circle point). *p < 0.01. (g) Focal scores of SG sections evaluated from fifteen mice per genotype. Results are expressed as mean ± SD of mean values of the scores of four SG sections per animal. *p < 0.01.