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. 2018 Sep 24;8:14272. doi: 10.1038/s41598-018-32690-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MyD88-dependent HEV formation-associated changes in SGs from NOD mice. (a) qRT-PCR analysis of Glycam1 expression in whole SMG tissues from 12-week-old female Myd88^+/+ and Myd88^−/− NOD mice (n = 8 per genotype). Expression levels were calculated relative to Hprt expression. Results are expressed as mean ± SD (bar graph). *p < 0.01. (b) Representative areas of anti-PNAd (MECA-79) antibody-stained sections of SGs from Myd88^+/+ (left) and Myd88^−/− (right) NOD mice. Arrows and arrowheads indicate HEV-like vessels and probable HEV precursor cells, respectively. Original magnification: ×20. (c) Flow cytometric analysis of CD62L in cells prepared from spleen (upper) and SGALNs (lower) from 12-week-old female Myd88^+/+ (left) and Myd88^−/− (right) NOD mice was performed. Black lines indicate all cells; red lines indicate CD3+ cells, green lines indicate B220+ cells. Results are representative of three independent experiments.