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. 2018 Sep 24;8:14272. doi: 10.1038/s41598-018-32690-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MyD88-dependent expression of lymphoid chemokines in SGs from NOD mice. (a) Microarray analysis showing reduced expression of chemokine genes in SMGs from 10-week-old female Myd88^−/− B6 mice relative to Myd88^+/+ B6 mice (n = 3 per genotype). (b) qRT-PCR analysis of Ccl19 and Cxcx13 expression in whole SMGs from 12-week-old female Myd88^+/+ and Myd88^−/− NOD mice (n = 6 per genotype). Expression levels calculated relative to Hprt expression. Results are expressed as mean ± SD (bar graph). *p < 0.01. (c) Flow cytometric analysis of CCR7 and CXCR5 in cells prepared from spleen (left) and SGALNs (right) from Myd88^+/+ (red lines) and Myd88^−/− (blue lines) NOD mice. Black lines indicate cells stained with an isotype control antibody from Myd88^+/+ NOD mice. Results are representative of three independent experiments.