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. 2018 Sep;59(11):4670–4682. doi: 10.1167/iovs.18-24427

Figure 4.

Figure 4

GRP78 attenuates TON-induced ER stress. TON was performed at 4 to 5 weeks after intravitreal injection of AAV2-Null or GRP78, and eyes were collected at 3 days after TON. Immunostaining was performed on retinal frozen sections. (A) Representative images of p-PERK, ATF6, ATF4, and CHOP expressions in the GCL. Arrowheads indicate nonspecific vessel staining. (B) Bar graphs represent quantification of p-PERK, ATF6, ATF4, and CHOP. n = 3–4, *P < 0.05 versus relevant control, #P < 0.05, AAV2-Null-TON versus AAV2-GRP78-TON. Scale bar: 50 μm.