Table 2.

Cross-sectional associations between log copeptin levels and risk of pregnancy complications, CPEP case-cohort

Outcomes	N*	Crude OR (95% CI)	p-value	Adjusted OR (95% CI)†	p-value
Baseline copeptin (<22 weeks GA)		vs. 136 controls
Preeclampsia (all cases)	158	1.61 (1.11–2.33)	0.01	1.55 (1.03–2.31)	0.03
Preterm PE (diagnosis <37 weeks)	63	1.73 (1.06–2.83)	0.03	1.86 (1.08–3.20)	0.03
Term PE (diagnosis ≥37 weeks)	95	1.58 (1.03–2.44)	0.04	1.45 (0.91–2.32)	0.12
Gestational Hypertension	101	1.20 (0.78–1.86)	0.41	1.33 (0.83–2.13)	0.24
Gestational diabetes	92	0.87 (0.56–1.36)	0.55	1.23 (0.72–2.12)	0.45
Preterm birth without PE	86	1.83 (1.14–2.94)	0.01	1.46 (0.87–2.46)	0.15
Second copeptin (22–32 weeks GA)		vs. 115 controls
Preeclampsia (all cases)	144	2.07 (1.33–3.21)	0.001	2.06 (1.28–3.31)	0.003
Preterm PE (diagnosis <37 weeks)	57	2.59 (1.47–4.57)	0.001	2.76 (1.45–5.10)	0.001
Term PE (diagnosis ≥37 weeks)	87	1.70 (1.05–2.76)	0.03	1.68 (0.99–2.86)	0.05
Gestational hypertension	92	1.32 (0.83–2.11)	0.24	1.37 (0.83–2.28)	0.22
Gestational diabetes	81	1.10 (0.69–1.75)	0.69	1.25 (0.72–2.16)	0.43
Third copeptin (33–38 weeks GA)		vs. 110 controls
Preeclampsia (all cases)	99	2.64 (1.58–4.40)	0.0002	2.52 (1.42–4.50)	0.002
Preterm PE (diagnosis <37 weeks)	14	5.16 (1.87–14.27)	0.002	8.56 (1.97–37.24)	0.004
Term PE (diagnosis ≥37 weeks)	85	2.37 (1.38–4.07)	0.002	2.40 (1.28–4.50)	0.007
Gestational hypertension	77	1.23 (0.75–2.03)	0.41	1.53 (0.85–2.73)	0.15

Abbreviation: GA, gestational age; PE, preeclampsia; OR, odds ratio

^*Four term PE cases and 22 gestational hypertension cases also had GDM.

^†Adjusted for age, race, BMI, current smoking, married, private insurance, and clinical site