Fig 4. GM-1111 reduces CRS-associated sinonasal inflammation in mice.

Microscopic images of sinonasal tissues stained with hematoxylin and eosin show coronal sections and respective higher magnification images of the indicated region of the nasal septum (box) and ethmoturbinate tissue (circle). A. fumigatus administration resulted in marked degenerative changes and loss of cilia in all epithelial layers (arrows), increased inflammatory cell infiltration, and thickening of the nasal septum (star). These changes were much less pronounced in animals treated with GM-1111. Histopathological interpretations were generated using images from all animals (n = 12 per treatment group) with representative images demonstrated.