Table 4.
Clinical trials registered on the Clinicaltrials.gov database conducted on Mentha essential oil.
| “Mentha Essential Oil” Clinical Trials | |
|---|---|
| Study Title | Study of an Essential Oil and a Delmopinol Mouthrinse Effect on Dental Plaque Accumulation Index, Gingivitis Index and on Streptococcus Mutans, Lactobacillus, Aerobic and Anaerobic Oral Bacteria Colony Counts |
| Condition | Gingivitis—Dental Plaque Accumulation |
| Status | Completed |
| Start and Completion dates | April 2007–April 2008 |
| Study Type and Design | Interventional |
| Allocation: Randomized | |
| Endpoint Classification: Efficacy Study | |
| Intervention Model: Parallel Assignment | |
| Masking: Open Label | |
| Primary Purpose: Prevention | |
| Primary Outcome | Loe & Silness Gingival Index (1963) |
| Quigley, Hein & Turesky Dental Plaque Index (1970) | |
| Study Title | Essential Oils Mouthrinse and Dental Floss, Comparison of Efficacy on Interproximal Gingivitis and Dental Plaque Accumulation |
| Condition | Gingivitis Dental—Plaque Accumulation |
| Status | Completed |
| Start and Completion dates | September 2007–January 2008 |
| Study Type and Design | Interventional |
| Allocation: Randomized | |
| Endpoint Classification: Efficacy Study | |
| Intervention Model: Parallel Assignment | |
| Masking: Open Label | |
| Primary Purpose: Prevention | |
| Primary Outcome | Lobene Gingival Index |
| Saxton & Ouderaa Bleeding Index | |
| Quigley, Hein & Turesky Dental Plaque Index | |
| Study Title | Treatment of Acute Rhinosinusitis with Essential Oils of Aromatic Plants |
| Condition | Rhinosinusitis |
| Status | Completed |
| Start and Completion dates | January 2008–May 2008 |
| Study Type and Design | Interventional |
| Allocation: Randomized | |
| Endpoint Classification: Efficacy Study | |
| Intervention Model: Parallel Assignment | |
| Masking: Double Blind (Subject, Investigator) | |
| Primary Purpose: Treatment | |
| Primary Outcome | To demonstrate a relief in the nasal obstruction within the first 20 min after first administration of treatment with the spray |
| Study Title | Treatment of Acute Pharyngo-Tonsillitis with Essential Oils of Aromatic Plants |
| Condition | Viral Pharyngitis—Viral Tonsillitis |
| Status | Completed |
| Start and Completion dates | January 2008–May 2008 |
| Study Type and Design | Interventional |
| Allocation: Randomized | |
| Endpoint Classification: Efficacy Study | |
| Intervention Model: Parallel Assignment | |
| Masking: Double Blind (Subject, Investigator) | |
| Primary Purpose: Treatment | |
| Primary Outcome | To demonstrate a throat pain relief within the first 20 min after first administration of treatment with the spray. |
| Study Title | Treatment of Acute Tracheitis and Laryngitis with Essential Oils of Aromatic Plants |
| Condition | Viral Laryngitis—Viral Tracheitis |
| Status | Completed |
| Start and Completion dates | January 2008–May 2008 |
| Study Type and Design | Interventional |
| Allocation: Randomized | |
| Endpoint Classification: Efficacy Study | |
| Intervention Model: Parallel Assignment | |
| Masking: Double Blind (Subject, Investigator) | |
| Primary Purpose: Treatment | |
| Primary Outcome | To demonstrate a cough or hoarseness relief within the first 20 min after first administration of treatment with the spray |
| Study Title | Dental Implants and Mouth Rinse |
| Condition | Reduction in Bacterial Counts Through the Use of Mouthwash |
| Status | Recruiting |
| Start and Completion dates | November 2013–June 2016 (hypothesized) |
| Study Type and Design | Interventional |
| Allocation: Randomized | |
| Endpoint Classification: Efficacy Study | |
| Intervention Model: Parallel Assignment | |
| Masking: Open Label | |
| Primary Purpose: Supportive Care | |
| Primary Outcome | Oral Rinse Comparison |
| Study Title | A Clinical Trial to Test the Effect of Marketed Mouth Rinses on Decreasing Plaque and Gum Inflammation |
| Condition | Plaque—Gingivitis |
| Status | Completed |
| Start and Completion dates | August 2014–September 2014 |
| Study Type and Design | Interventional |
| Allocation: Randomized | |
| Endpoint Classification: Safety/Efficacy Study | |
| Intervention Model: Parallel Assignment | |
| Masking: Single Blind (Investigator) | |
| Primary Outcome | Whole Mouth Mean Modified Gingival Index (MGI) at Week 3 |
| Whole Mouth Mean Plaque Index (PI) at Week 3 | |
| Study Title | Freeze Remedy to Alleviate Morning Sickness |
| Condition | Morning Sickness |
| Status | Recruiting |
| Start and Completion dates | August 2014–February 2015 (hypothesized) |
| Study Type and Design | Interventional |
| Allocation: Randomized | |
| Endpoint Classification: Efficacy Study | |
| Intervention Model: Parallel Assignment | |
| Masking: Double Blind (Subject, Caregiver) | |
| Primary Purpose: Treatment | |
| Primary Outcome | Improvement of Nausea and Vomiting of Pregnancy (NVP) |