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. 2017 Jan 21;22(1):167. doi: 10.3390/molecules22010167

Table 1.

Determination of HF anticlastogenic effect towards benzo(a)pyrene using the chromosome aberration test on HepG2 cells.

HF/B(a)P Concentration (µM) Number of Aberrant Metaphases Number of Chromosome Aberrations Total Number of CA
Chromatid Isochromatid Exchange
g b/f g b/f ring dic qr tr dmin
HepG2
IC 4 1 3 - - - - - - 1 4
SC 3 1 3 - - - - - - - 3
HF 0.75 2 1 2 - - - - - - - 2
HF 1.5 2 - 2 - - - - - - - 2
PC B(a)P 1.7 35 *** - 33 1 5 - 1 - - - 39 ***
HF 0.75 + B(a)P 1.7 8 ### 1 7 - 1 - - - - - 8 ###
HF 1.5 + B(a)P 1.7 8 ### 1 8 - - - 1 - - - 9 ###

IC—intact control; SC—solvent control (DMSO); HF—hyperforin; PC B(a)P—positive control (benzo(a)pyrene); CA—chromosome aberrations; g—gap; b/f—break and/or fragment; dic—dicentric; qr—quadriradial; tr—triradial. Comparison with solvent control (SC): *** p < 0.001. Comparison with positive control (PC): ###p < 0.001.