Table 2.

Polymer-drug conjugates and micelles containing artemisinin derivatives.

Polymer	Artemisinin Derivatives	Drug Delivery System	Application	Advantages	Ref.
Polyethylene glycol	Dihydroartemisinin	Polymer-drug conjugate	Antitumor	Enhanced solubility, long circulating half-life and improved antitumor effect.	[40,42]
Hydroxypropyl-β-cyclodextrin	Dihydroartemisinin	Polymer-drug conjugate	Oral administration	Increased solubility and stability of dihydroartemisinin.	[41]
Cyclodextrin via vinyl-acyl fatty esters	Artemisinin	Polymer-drug conjugate	Antimalarial by injection.	Effective antimalarial effect against P. falciparum.	[43]
Chitosan	Artemisinin	Polymer-drug conjugate	-	Improved solubility of artemisinin than the free artemisinin.	[44]
Polyorgano-phosphazenes	Primaquine and dihydroartemisinin	Polymer-drug conjugate	Antimalarial	Effective for combination therapy against drug resistant strain of P. berghei infected mice with 100% antimalarial activity.	[45]
Methoxy-polyethylene glycol	Artemether	Micelles	Antimalarial	Enhanced drug stability with prolonged release of artemether.	[46]
Polyurethane	Arteether	Micelles	Anticancer	Significant inhibition of the growth of 4T1 cell line.	[47]
PEG-PCL	Artemisinin	Micelles	Antitumor	High cellular uptake and inhibition effects on cancer cell lines with good antitumor efficacy.	[48]
Methoxy poly(ethylene glycol)/poly(l-lactic acid)	Dihydroartemisinin	Micelles	Anticancer	Better solubilizing ability than dihydroartemisinin suspension.	[49]