Table 4.
Integrated PK parameters of the CR and EF alkaloids in rat plasma after oral administration of ZJ and FZJ extract (mean ± SD, n = 6).
| PK Parameters | Integrated Method | ZJ | FZJ | ||
|---|---|---|---|---|---|
| CR Alkaloids | EF Alkaloids | CR Alkaloids | EF Alkaloids | ||
| AUC0→t (ng·h/mL) | A | 165.85 ± 25.24 | 454.02 ± 49.50 | 31.01 ± 4.38 | 222.33 ± 18.87 |
| B | 740.58 ± 96.29 | 632.55 ± 69.91 | 97.24 ± 12.03 | 352.74 ± 31.92 | |
| AUC0→∞ (ng·h/mL) | A | 174.90 ± 23.60 | 458.50 ± 46.98 | 36.92 ± 8.61 | 230.95 ± 19.29 |
| B | 790.50 ± 129.01 * | 640.61 ± 64.83 * | 113.78 ± 19.69 * | 368.20 ± 33.08 * | |
| MRT0→t (min) | A | 465.48 ± 62.56 | 260.53 ± 15.54 | 251.24 ± 19.62 | 282.29 ± 55.06 |
| B | 498.47 ± 54.24 | 262.85 ± 17.19 | 243.73 ± 17.92 | 295.12 ± 49.32 | |
| MRT0→∞ (min) | A | 464.99 ± 65.15 | 283.73 ± 34.85 | 254.95 ± 60.94 | 359.90 ± 111.27 |
| B | 513.57 ± 53.75 | 293.62 ± 40.77 | 272.09 ± 72.64 | 373.48 ± 90.75 | |
| t1/2 (min) | A | 537.02 ± 408.47 | 195.02 ± 136.85 | 141.62 ± 31.75 | 303.14 ± 162.88 |
| B | 573.75 ± 447.62 | 218.36 ± 137.70 | 186.77 ± 91.91 | 334.42 ± 104.19 | |
| Tmax (min) | A | 90 | 240 | 180 | 90 |
| B | 90 | 240 | 180 | 90 | |
| Cmax (ng/mL) | A | 54.14 ± 22.14 | 131.18 ± 23.45 | 14.82 ± 4.70 | 67.02 ± 10.36 |
| B | 198.70 ± 76.91 * | 167.10 ± 28.40 * | 43.79 ± 14.12 * | 92.367 ± 12.51 * | |
| Tsec (min) | A | 300 | 90 | 30 | - |
| B | 300 | 90 | 30 | - | |
| Csec (ng/mL) | A | 24.99 ± 10.08 | 99.90 ± 38.75 | 7.51 ± 4.19 | - |
| B | 113.27 ± 40.70 | 138.18 ± 54.42 | 25.35 ± 10.26 | - | |
A denoted the AUC-based weighting method, and B denoted the total drug concentration method. * p < 0.05 compared with method A.