Table 6.
Pharmacokinetic parameters of compounds 1–11 after oral administration of different decoctions in normal rats (n = 6).
| Compound No. | Group | Cmax/ng·mL−1 | Tmax/h | T1/2/h | AUC0~t/ng·h·mL−1 |
|---|---|---|---|---|---|
| 1 | HYD | 1595.00 ± 595.18 | 0.19 ± 0.11 | 9.23 ± 5.85 | 1762.25 ± 286.64 |
| HYD-HZ | 493.56 ± 164.61 ** | 0.31 ± 0.07 ** | 3.66 ± 3.30 | 987.22 ± 566.92 * | |
| GH | 254.11 ± 121.96 | 0.17 ± 0 ** | 1.34 ± 1.48 | 2509.26 ± 814.35 ** | |
| GC | 147.34 ± 37.69 | 0.67 ± 0 | 0.99 ± 0.34 | 229.19 ± 118.70 | |
| 2 | HYD | 612.10 ± 200.05 | 0.17 ± 0.09 | 11.33 ± 4.86 | 911.65 ± 197.89 |
| HYD-GC | 271.49 ± 75.41 | 0.19 ± 0.07 | 1.12 ± 0.28 | 561.47 ± 278.27 | |
| HYD-HZ | 462.81 ± 193.77 | 0.50 ± 0.18 | 2.59 ± 2.02 | 1060.95 ± 243.51 | |
| HYD-GH | 423.79 ± 188.45 | 0.15 ± 0.10 | 1.23 ± 0.15 ## | 565.30 ± 351.95 | |
| 3 | HYD | 302.93 ± 95.12 | 0.24 ± 0.21 | 1.15 ± 0.34 | 359.29 ± 120.84 |
| HYD-GC | 67.96 ± 9.34 | 0.13 ± 0.05 | 1.51 ± 0 | 85.93 ± 41.99 | |
| HYD-HZ | 46.81 ± 21.32 | 0.44 ± 0.17 | 0.21 ± 0.12 | 52.82 ± 56.56 | |
| HYD-GH | 119.82 ± 21.24 ## | 0.17 ± 0 | 0.52 ± 0.50 # | 100.09 ± 44.85 ## | |
| 4 | HYD | 119.89 ± 68.18 | 4.38 ± 4.76 | 30.56 ± 13.26 | 3795.89 ± 2093.85 |
| HYD-GC | 196.55 ± 54.12 | 1.42 ± 0.91 * | 5.40 ± 1.47 | 1280.46 ± 287.94 | |
| HYD-HZ | 358.38 ± 104.88 | 0.17 ± 0 | 7.64 ± 2.44 | 825.21 ± 81.47 | |
| HYD-GH | 122.63 ± 0.15 | 0.17 ± 0.15 | 4.52 ± 0.56 ## | 501.22 ± 414.00 # | |
| 5 | HYD | 197.09 ± 115.14 | 3.17 ± 2.56 | 3.44 ± 2.84 | 1170.96 ± 569.74 |
| HYD-GC | 169.17 ± 45.26 | 1.11 ± 0.46 | 1.75 ± 0.99 | 768.95 ± 246.38 | |
| HYD-HZ | 274.30 ± 76.06 | 2.08 ± 1.68 | 5.82 ± 2.46 | 2292.23 ± 244.80 | |
| HYD-GH | 302.24 ± 62.36 | 3.11 ± 1.44 | 4.70 ± 1.96 | 1043.15 ± 549.78 | |
| 6 | HYD | 357.96 ± 91.94 | 2.75 ± 4.07 | 4.05 ± 0.77 | 39.27.33 ± 554.59 |
| HYD-HZ | 275.66 ± 66.54 | 0.79 ± 1.58 | 3.94 ± 0.59 | 2146.24 ± 629.49 | |
| GH | 211.11 ± 70.27 | 1.50 ± 1.23 | 4.12 ± 3.73 | 681.38 ± 771.03 * | |
| GC | 220.40 ± 47.43 | 2.50 ± 1.73 | 2.41 ± 1.57 | 1000.77 ± 945.93 | |
| 7 | HYD | 1373.60 ± 711.55 | 0.292 ± 0.10 | 1.58 ± 1.01 | 1689.27 ± 638.54 |
| HYD-HZ | 587.45 ± 261.23 | 0.67 ± 0.42 | 1.84 ± 1.82 | 587.45 ± 261.23 | |
| GH | 1345.54 ± 321.92 ** | 0.56 ± 0.40 | 9.94 ± 8.89 | 3597.01 ± 1839.69 * | |
| GC | 607.13 ± 137.38 | 1.25 ± 0.50 | 4.47 ± 2.63 | 1762.95 ± 1426.16 | |
| 8 | HYD | 226.76 ± 57.80 | 0.33 ± 0.21 | 1.56 ± 1.02 | 819.43 ± 25.72 |
| HYD-GC | 183.32 ± 46.99 | 0.61 ± 0.14 | 1.17 ± 0.10 | 469.69 ± 129.75 | |
| HYD-HZ | 191.83 ± 54.52 | 0.81 ± 0.34 | 1.92 ± 1.75 | 649.05 ± 132.42 | |
| HYD-GH | 125.28 ± 35.61 | 0.11 ± 0.04 ## | 9.60 ± 10.61 | 785.69 ± 369.20 ## | |
| 9 | HYD | 1000.95 ± 178.16 | 0.67 ± 0 | 6.03 ± 1.95 | 2865.70 ± 285.38 |
| HYD-GC | 501.42 ± 182.99 | 0.89 ± 0.27 | 4.53 ± 1.89 | 2005.59 ± 1023.79 | |
| HYD-HZ | 321.98 ± 88.25 | 0.19 ± 0.07 | 16.18 ± 7.06 | 2293.06 ± 55.53 | |
| HYD-GH | 311.16 ± 126.03 ## | 0.46 ± 0.37 | 3.26 ± 3.53 | 1182.52 ± 539.49 ## | |
| 10 | HYD | 457.96 ± 184.11 | 0.61 ± 0.14 | 1.25 ± 0.03 | 748.45 ± 224.96 |
| HYD-GC | 101.03 ± 31.86 | 0.39 ± 0.14 | 1.54 ± 0.51 | 204.75 ± 94.67 | |
| HYD-HZ | 294.65 ± 116.62 | 0.61 ± 0.25 | 1.45 ± 1.11 | 294.65 ± 116.62 | |
| HYD-GH | 69.22 ± 25.57 ## | 0.53 ± 0.31 | 0.68 ± 0.49 # | 98.46 ± 40.96 ## | |
| 11 | HYD | 504.27 ± 100.76 | 9.33 ± 2.07 | 3.01 ± 2.35 | 9987.32 ± 1663.21 |
| HYD-HZ | 756.10 ± 58.12 | 12.00 ± 0 | 1.99 ± 0.03 | 12,692.39 ± 1489.22 | |
| GH | 1247.75 ± 210.12 * | 12.67 ± 5.89 | 1.93 ± 0.04 | 22,825.00 ± 10,422.15 | |
| GC | 776.14 ± 184.15 | 10.00 ± 2.31 | 4.66 ± 5.33 | 10,451.95 ± 8308.34 |
Data are expressed as mean ± S.D. (n = 6); * Difference compared with the corresponding GC group, p < 0.05; ** Difference compared with the corresponding GC group, p < 0.01; # Difference compared with the corresponding HYD group, p < 0.05; ## Difference compared with the corresponding HYD group, p < 0.01.