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. 2016 Dec 28;22(1):36. doi: 10.3390/molecules22010036

Figure 6.

Figure 6

XN decreases the cancer stem-like cell markers of MCF-7/ADR. (A) XN regulates the expression of cancer stem-like cell markers. The biomarkers related to the stemness in MCF-7/ADR cells were measured by western blotting after treated with XN for 48 h; (B) protein levels quantified by scanning densitometry and normalized to control. Results are expressed as a ratio of control. Data represent means ± SD from three independent experiments. * p < 0.05, ** p < 0.01 for control cells versus XN treated cells; (C) XN reduces the percentage of CD44+/CD24− breast cancer stem-like cells. The phenotype of CD44+/CD24− cells was measured by flow cytometry after treatment with 5 and 10 μM XN for 48 h; (D) The histogram shows the decreased population of CD44+/CD24− cells. Results are normalized to untreated cells and the data shown are the means ± SD of three experiments for each group. * p < 0.05, ** p < 0.01 versus medium control.